Endocrine Abstracts

IGF1 concentrations have been reported to increase with 25-hydroxyvitamin D (25(OH)D) values in population studies, but it is unclear whether this association expresses a cause-effect relationship. Mice genetically deficient of steroid receptor coactivator 3, a transcriptional coactivator for the nuclear vitamin D receptor, have significantly lower circulating IGF1 levels than wild-types.We measured serum fasting 25(OH)D and IGF1 by enzyme- and radioimmu...